Plant Transcription Factor Database
Previous version: v3.0
Lotus japonicus
NF-YA Family
Species TF ID Description
Lj0g3v0252369.1NF-YA family protein
Lj1g3v4752710.1NF-YA family protein
Lj1g3v4752710.2NF-YA family protein
Lj1g3v4752710.3NF-YA family protein
Lj2g3v3336090.1NF-YA family protein
Lj3g3v0338970.1NF-YA family protein
Lj3g3v0338970.2NF-YA family protein
Lj3g3v0338970.3NF-YA family protein
Lj3g3v2657800.1NF-YA family protein
Lj4g3v2179250.1NF-YA family protein
Lj5g3v0841080.1NF-YA family protein
Lj5g3v0841080.2NF-YA family protein
Lj6g3v0647470.1NF-YA family protein
NF-YA Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

NF-YA proteins are characterized by the presence of Gln(Q)- and Ser/Thr(S/T)-rich NH2 termini, a subunit interaction domain (NF-YB/NF-YC interaction), and a DNA-binding domain (Olesen and Guarente, 1990; Maity and de Crombrugghe, 1992; Xing et al., 1993, 1994). The protein interaction and DNA binding domains are well conserved between plant and other eukaryote lineages.

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982